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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-PF-04991532
PF-04991532

Chemical Structure : PF-04991532

CAS No.: 1215197-37-7

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PF-04991532 (PF4991532, PF 04991532)

货号: PC-61880Not For Human Use, Lab Use Only.

PF-04991532 (PF4991532) is a potent, hepatoselective Glucokinase (GK) activator with EC50 of 90±45 nM.

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10 mg ￥1480 In stock
25 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-04991532 (PF4991532) is a potent, hepatoselective Glucokinase (GK) activator with EC50 of 90±45 nM.
PF-04991532 displays >50-fold liver-to-pancreas ratio of tissue distribution in rodent and non-rodent species.
PF-04991532 robustly lowers fasting and postprandial glucose with no hypoglycemia in vivo.

物理化学性质&存储条件

分子量 396.37
分子式 C18H19F3N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid

参考文献

1. Pfefferkorn JA, et al. J Med Chem. 2012 Feb 9;55(3):1318-33.

2. Erion DM, et al. PLoS One. 2014 May 23;9(5):e97139.

3. Ghosh A, et al. Drug Metab Dispos. 2014 Oct;42(10):1599-610.

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