PF-04979064 |CAS:1220699-06-8 Probechem Biochemicals

Chemical Structure : PF-04979064

CAS No.: 1220699-06-8

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PF-04979064 (PF 04979064;PF04979064)

货号: PC-42133Not For Human Use, Lab Use Only.

PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
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生物&药学活性

PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively.
PF-04979064 exhibits excellent in vitro potency, very good solubility, high LipE, excellent kinome selectivity, robust PK/PD correlation and TGI efficacy, and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism.

物理化学性质&存储条件

分子量	446.5016
分子式	C24H26N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 11 mg/mL
Chemical Name/SMILES	2H-Imidazo[4,5-c][1,5]naphthyridin-2-one, 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-

参考文献

1. Cheng H, et al. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7.

PF-04979064 (PF 04979064;PF04979064)

生物&药学活性

物理化学性质&存储条件

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PF-04979064 (PF 04979064;PF04979064)

生物&药学活性

物理化学性质&存储条件

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