PF-04859989 | Kynurenine aminotransferase II inhibitor

Chemical Structure : PF-04859989

CAS No.: 34783-48-7

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PF-04859989 (PF 04859989)

货号: PC-20567Not For Human Use, Lab Use Only.

PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
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生物&药学活性

PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.
PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50 values of 22, 11, and >50 μM, respectively).
PF-04859989 is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).

物理化学性质&存储条件

分子量	178.19
分子式	C9H10N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N

参考文献

1. Dounay AB, et al. ACS Med Chem Lett. 2012 Jan 25;3(3):187-92.

PF-04859989 (PF 04859989)

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物理化学性质&存储条件

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PF-04859989 (PF 04859989)

生物&药学活性

物理化学性质&存储条件

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