PF-04802367 (PF-367) | GSK-3 inhibitor | Probechem Biochemicals

Chemical Structure : PF-04802367

CAS No.: 1962178-27-3

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PF-04802367 (PF04802367, PF-367)

货号: PC-61159Not For Human Use, Lab Use Only.

A potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

PF-04802367 (PF-367) is a potent, highly selective GSK-3 inhibitor with IC50 of 2.1 nM for human GSK-3β in enzyme assays.
PF-04802367 shows equal effectivity against GSK-3α and GSK-3β with IC50 of 10.0 and 9.0 nM respectively in mobility shift assays.
PF-04802367 inhibits phosphorylation of tau with an IC50 of 466 nM in a stable inducible CHO cell line over-expressing GSK-3β and substrate tau.
PF-04802367 modulates tau phosphorylation in vitro and in vivo.

物理化学性质&存储条件

分子量	361.786
分子式	C16H16ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide

参考文献

1. Liang SH, et al. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9601-5.

PF-04802367 (PF04802367, PF-367)

生物&药学活性

物理化学性质&存储条件

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PF-04802367 (PF04802367, PF-367)

生物&药学活性

物理化学性质&存储条件

参考文献

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