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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-PF-04781340
PF-04781340

Chemical Structure : PF-04781340

CAS No.: 1648726-56-0

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PF-04781340 (PF 04781340, PF04781340)

货号: PC-61080Not For Human Use, Lab Use Only.

PF-04781340 is a potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-04781340 is a potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.
    PF-04781340 displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM).
    PF-04781340 exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.

    物理化学性质&存储条件

    分子量 267.376
    分子式 C17H21N3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-benzyl-N-methyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepin-1-amine

    参考文献

    1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

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