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首页-小分子抑制剂&激动剂-GPCR-Cholecystokinin Receptor-PF-04756956
PF-04756956

Chemical Structure : PF-04756956

CAS No.: 1228934-52-8

PF-04756956 (PF04756956;PF 04756956)

货号: PC-70198Not For Human Use, Lab Use Only.

PF-04756956 is a potent, selective CCK1 receptor agonist with EC50 of 0.47 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-04756956 is a potent, selective CCK1 receptor agonist with EC50 of 0.47 nM.
    PF-04756956 elicits no biological response at the CCK2 receptors.
    PF-04756956 demonstrates robust weight loss in a diet-induced obese rat model with very low systemic exposure.

    物理化学性质&存储条件

    分子量 649.799
    分子式 C40H39N7O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (4S)-4-((1H-indazol-3-yl)methyl)-6-(2-((R)-2-(3,5-dimethylbenzyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-5(6H)-one

    参考文献

    1. Desai AJ, et al. J Med Chem. 2015 Dec 24;58(24):9562-77.

    2. Cameron KO, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2943-7.

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