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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PF-04677490
PF-04677490

Chemical Structure : PF-04677490

CAS No.: 1628342-10-8

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PF-04677490 (PF04677490)

货号: PC-63526Not For Human Use, Lab Use Only.

PF-04677490 is a potent, selective PDE1 inhibitor with IC50 of 21 nM for PDE1B.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-04677490 is a potent, selective PDE1 inhibitor with IC50 of 21 nM for PDE1B.
    PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity in preparations from human myocardium at concentrations selective for PDE1.

    物理化学性质&存储条件

    分子量 327.388
    分子式 C17H21N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7,8-dimethoxy-N-(1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl)quinazolin-4-amine

    参考文献

    1. Humphrey JM, et al. J Med Chem. 2018 May 10. doi: 10.1021/acs.jmedchem.8b00374.

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