PF-04634817 succinate | CCR2/CCR5 inhibitor | Probechem Biochemicals

Chemical Structure : PF-04634817 succinate

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PF-04634817 succinate (PF4634817 succinate)

货号: PC-61559Not For Human Use, Lab Use Only.

PF-04634817 succinate is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist with IC50 of 20.8 nM (human and rodent CCR2), 470 nM (rat CCR5).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

PF-04634817 succinate is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist with IC50 of 20.8 nM (human and rodent CCR2), 470 nM (rat CCR5).
PF-04634817 shows potential for the treatment of diabetic nephropathies and diabetic macular oedema.

物理化学性质&存储条件

分子量	629.67
分子式	C25H36F3N5O3 · C4H6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)((1S,4S)-5-(6-(trifluoromethyl)pyrimidin-4-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methanone succinate

参考文献

1. Tesch GH, et al. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1439-F1449.
2. Gale JD, et al. Kidney Int Rep. 2018 Aug 3;3(6):1316-1327.

PF-04634817 succinate (PF4634817 succinate)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-04634817 succinate (PF4634817 succinate)

生物&药学活性

物理化学性质&存储条件

参考文献

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