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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-PF-04634817
PF-04634817

Chemical Structure : PF-04634817

CAS No.: 1228111-63-4

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PF-04634817 (PF04634817, PF 4634817)

货号: PC-61558Not For Human Use, Lab Use Only.

PF-04634817 is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist with IC50 of 20.8 nM (human and rodent CCR2), 470 nM (rat CCR5).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-04634817 is a potent, orally bioavailble CCR2 and CCR5 chemokine receptor antagonist with IC50 of 20.8 nM (human and rodent CCR2), 470 nM (rat CCR5).
    PF-04634817 shows potential for the treatment of diabetic nephropathies and diabetic macular oedema.

    物理化学性质&存储条件

    分子量 511.59
    分子式 C25H36F3N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)((1S,4S)-5-(6-(trifluoromethyl)pyrimidin-4-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methanone

    参考文献

    1. Tesch GH, et al. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1439-F1449.
    2. Gale JD, et al. Kidney Int Rep. 2018 Aug 3;3(6):1316-1327.

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