PF-04620110 | DGAT1 inhibitor | Probechem Biochemicals

Chemical Structure : PF-04620110

CAS No.: 1109276-89-2

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PF-04620110 (PF 04620110, PF04620110)

货号: PC-43318Not For Human Use, Lab Use Only.

PF-04620110 is a potent, selective, orally bioavailable DGAT-1 inhibitor with IC50 of 19 nM, shows no acitivity for DGAT-2 (IC50>30 uM).

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2680	In stock
100 mg		Get quote

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生物&药学活性

PF-04620110 is a potent, selective, orally bioavailable DGAT-1 inhibitor with IC50 of 19 nM, shows no acitivity for DGAT-2 (IC50>30 uM).
PF-04620110 shows high selectivity versus a broad panel of off-target pharmacologic end points.
PF-04620110 inhibits triglyceride synthesis of 3 in the intestinal-derived HT-29 cell line with IC50 of 8 nM.
PF-04620110 demonstrates in vivo DGAT-1 inhibitionthrough reduction of plasma triglyceride levels in rodent, alters the temporal and spatial pattern of dietary lipid absorption in vivo.

物理化学性质&存储条件

分子量	396.4397
分子式	C21H24N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexaneacetic acid, 4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-, trans-

参考文献

1. Dow RL, et al. ACS Med Chem Lett. 2011 Mar 18;2(5):407-12.

2. Maciejewski BS, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G958-69.

3. Maciejewski BS, et al. World J Gastrointest Pathophysiol. 2017 Nov 15;8(4):161-175.

PF-04620110 (PF 04620110, PF04620110)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-04620110 (PF 04620110, PF04620110)

生物&药学活性

物理化学性质&存储条件

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