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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-FAAH-PF-04457845
PF-04457845

Chemical Structure : PF-04457845

CAS No.: 1020315-31-4

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PF-04457845 (Redafamdastat, PF 04457845)

货号: PC-20049Not For Human Use, Lab Use Only.

PF-04457845 (Redafamdastat) is a highly potent, selective and covalent fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 7.2 nM (human FAAH).

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-04457845 (Redafamdastat) is a highly potent, selective and covalent fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 7.2 nM (human FAAH).
PF-04457845 displays no activity against other FP-reactive serine hydrolases at 100 uM, as well as a broad panel of 68 targets including receptors, enzymes, ion channels, and transporters.
PF-04457845 is orally bioavailable, and PF-04457845 (10 mg/kg, p.o.) displays antihyperalgesic activity with long duration of action in the CFA model of inflammatory pain in rats.
PF-04457845 does not elicit effect in motility, catalepsy, and body temperature.

物理化学性质&存储条件

分子量 455.44
分子式 C23H20F3N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide

参考文献

1. Sébastien Dilly, et al. Antioxidants (Basel). 2023 Feb 10;12(2):440.

2. Li Yet al. Proc. Natl. Acad. Sci. USA. 2012;109:12526–12531.

3. Ahn K, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24.

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