PF-04455242 hydrochloride | KOR antagonist | Probechem Biochemicals

Chemical Structure : PF-04455242 hydrochloride

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PF-04455242 hydrochloride (PF-4455242)

货号: PC-62109Not For Human Use, Lab Use Only.

PF-04455242 hydrochloride is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively.

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生物&药学活性

PF-04455242 hydrochloride is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively.
PF-04455242 shows 20-fold reduced affinity for hMOR and negligible affinity for DOR (Ki>4 uM).
PF-04455242 demonstrates antidepressant-like efficacy, attenuates the behavioral effects of stress, dose-dependently reduceds the elevation of spiradoline-induced plasma prolactin in rats.

物理化学性质&存储条件

分子量	408.985
分子式	C21H29ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-N-[[4-(2-pyrrolidin-1-ylsulfonylphenyl)phenyl]methyl]propan-1-amine hydrochloride

参考文献

1. Verhoest PR, et al. J Med Chem. 2011 Aug 25;54(16):5868-77.

2. Grimwood S, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):555-66.

3. Melief EJ, et al. Mol Pharmacol. 2011 Nov;80(5):920-9.

PF-04455242 hydrochloride (PF-4455242)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-04455242 hydrochloride (PF-4455242)

生物&药学活性

物理化学性质&存储条件

参考文献

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