PF-04217903 |CAS:956905-27-4 Probechem Biochemicals

Chemical Structure : PF-04217903

CAS No.: 956905-27-4

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PF-04217903 (PF04217903;PF 04217903)

货号: PC-42832Not For Human Use, Lab Use Only.

PF-04217903 is a potent, selective, ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM, inhibits HGF-stimulated tyrosine phosphorylation of wild type c-Met with IC50 of 7.3 nM in cell-based assays.

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生物&药学活性

PF-04217903 is a potent, selective, ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM, inhibits HGF-stimulated tyrosine phosphorylation of wild type c-Met with IC50 of 7.3 nM in cell-based assays.
PF-04217903 shows similar potency for inhibition of c-Met phosphorylation in mIMCD3 mouse epithelial cells (IC50=6.9 nM) and MDCK cell (IC50=9.5 nM).
PF-04217903 also exhibits inhibitory activities against c-Met mutations including V1092I, H1094R, M1250T, R988C, and T11010I (IC50=530 nM), but has little to no activity against mutants Y1230C and Y1235D.
PF-04217903 inhibits tumor cell proliferation, survival, migration/invasion both in vitro and in vivo.

物理化学性质&存储条件

分子量	372.3833
分子式	C19H16N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-1-ethanol, 4-[1-(6-quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-

参考文献

1. Zou HY, et al. Mol Cancer Ther. 2012 Apr;11(4):1036-47.

2. Sennino B, et al. Cancer Res. 2013 Jun 15;73(12):3692-703.

3. Cui JJ, et al. J Med Chem. 2012 Sep 27;55(18):8091-109.

4. Yeh I, et al. Nat Commun. 2015 May 27;6:7174.

PF-04217903 (PF04217903;PF 04217903)

生物&药学活性

物理化学性质&存储条件

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PF-04217903 (PF04217903;PF 04217903)

生物&药学活性

物理化学性质&存储条件

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