PF-04191834 |CAS:1029317-21-2 Probechem Biochemicals

Chemical Structure : PF-04191834

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PF-04191834 (PF-4191834)

货号: PC-61882Not For Human Use, Lab Use Only.

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.

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生物&药学活性

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.

Pain

Phase 2 Discontinued

物理化学性质&存储条件

分子量	393.502
分子式	C22H23N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide

参考文献

1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.

2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.

PF-04191834 (PF-4191834)

生物&药学活性

物理化学性质&存储条件

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PF-04191834 (PF-4191834)

生物&药学活性

物理化学性质&存储条件

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