PF-03882845 (PF-3882845) | MR antagonist | Probechem Biochemicals

Chemical Structure : PF-03882845

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PF-03882845 (PF03882845, PF-3882845)

货号: PC-61848Not For Human Use, Lab Use Only.

PF-03882845 (PF-3882845) is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor (MR, MLR) antagonist with IC50 of 4.5 nM.

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生物&药学活性

PF-03882845 (PF-3882845) is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor (MR, MLR) antagonist with IC50 of 4.5 nM.
PF-03882845 displays >500-fold selectivity versus PR and other related nuclear hormone receptors.
PF-03882845 significantly increases urinary Na(+)/K(+) ratio in vivo.
PF-03882845 prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy.

物理化学性质&存储条件

分子量	419.91
分子式	C24H22ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid

参考文献

1. Casimiro-Garcia A, et al. J Med Chem. 2014 May 22;57(10):4273-88.

2. Orena S, et al. Front Pharmacol. 2013 Oct 14;4:115.

3. Eudy RJ, et al. J Transl Med. 2011 Oct 21;9:180.

PF-03882845 (PF03882845, PF-3882845)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-03882845 (PF03882845, PF-3882845)

生物&药学活性

物理化学性质&存储条件

参考文献

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