PF-03716556 |CAS:928774-43-0 Probechem Biochemicals

Chemical Structure : PF-03716556

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PF-03716556 (PF03716556)

货号: PC-62889Not For Human Use, Lab Use Only.

PF-03716556 is a potent, selective, competitive and reversible gastric H+,K+-ATPase with pIC50 of 7.0 in porcine ion-tight membrane vesicle.

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生物&药学活性

PF-03716556 is a potent, selective, competitive and reversible gastric H+,K+-ATPase with pIC50 of 7.0 in porcine ion-tight membrane vesicle; exhibits highly selective profile including the canine kidney Na+,K+-ATPase; inhibited gastric acid secretion in heidenhain pouch dogs (0.3-3mg/kg, p.o.), shows potentiation for the treatment of gastroesophageal reflux disease; orally biovailable.

物理化学性质&存储条件

分子量	394.5
分子式	C22H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide

参考文献

1. Mori H, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.

PF-03716556 (PF03716556)

生物&药学活性

物理化学性质&存储条件

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PF-03716556 (PF03716556)

生物&药学活性

物理化学性质&存储条件

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