PF-03246799 | 5-HT2C agonist | Probechem Biochemicals

Chemical Structure : PF-03246799

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PF-03246799 (PF 03246799;PF03246799;PF-3246799;PF3246799)

货号: PC-61081Not For Human Use, Lab Use Only.

PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.

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100 mg		Get quote

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生物&药学活性

PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.
PF-03246799 (PF-3246799) has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors.
PF-03246799 (PF-3246799)demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.

物理化学性质&存储条件

分子量	239.322
分子式	C15H17N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

参考文献

1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20.

2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

PF-03246799 (PF 03246799;PF03246799;PF-3246799;PF3246799)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PF-03246799 (PF 03246799;PF03246799;PF-3246799;PF3246799)

生物&药学活性

物理化学性质&存储条件

参考文献

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