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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PF-03049423
PF-03049423

Chemical Structure : PF-03049423

CAS No.: 954138-07-9

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PF-03049423 (PF 03049423)

货号: PC-61858Not For Human Use, Lab Use Only.

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
    PF-03049423 displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively.
    PF-03049423 possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.

    物理化学性质&存储条件

    分子量 468.55
    分子式 C24H32N6O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-pyrido[3,4-b]pyrazin-2(1H)-one

    参考文献

    1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60.

    2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.

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