PF-02413873 | PR antagonist | Probechem Biochemicals

Chemical Structure : PF-02413873

CAS No.: 936345-35-6

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PF-02413873 (PF-2413873, PF 02413873)

货号: PC-61896Not For Human Use, Lab Use Only.

PF-02413873 (PF-2413873) is a potent, selective, fully competitive, and orally active progesterone receptor (PR) antagonist with Ki of 9.7 nM.

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25 mg	￥2180	In stock
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生物&药学活性

PF-02413873 (PF-2413873) is a potent, selective, fully competitive, and orally active progesterone receptor (PR) antagonist with Ki of 9.7 nM.
PF-02413873 displays >30-fold selectivity over other homologous nuclear hormone receptors, GR, AR, and MR.
PF-02413873 blocks the follicular phase increase in endometrial thickness, the midcycle lutenizing hormone surge, and elevation in estradiol in a dose-dependent fashion compared with placebo in clinical trials.

物理化学性质&存储条件

分子量	359.44
分子式	C18H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-cyclopropyl-5-methyl-1-((methylsulfonyl)methyl)-1H-pyrazol-4-yl)oxy)-2,6-dimethylbenzonitrile

参考文献

1. Bungay PJ, et al. Drug Metab Dispos. 2011 Aug;39(8):1396-405.

2. Howe DC, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):642-53.

PF-02413873 (PF-2413873, PF 02413873)

生物&药学活性

物理化学性质&存储条件

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PF-02413873 (PF-2413873, PF 02413873)

生物&药学活性

物理化学性质&存储条件

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