欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-新冠病毒相关-SARS-CoV-2 Inhibitors-PF-00835231
PF-00835231

Chemical Structure : PF-00835231

CAS No.: 870153-29-0

加入收藏

PF-00835231 (PF 00835231)

货号: PC-72752Not For Human Use, Lab Use Only.

PF-00835231 (PF00835231) is a potent inhibitor of pan-coronavirus family 3CL pro (IC50=0.27 nM, SARS CoV-2), with selectivity over human host protease targets

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-00835231 (PF00835231) is a potent inhibitor of pan-coronavirus family 3CL pro (IC50=0.27 nM, SARS CoV-2), with selectivity over human host protease targets.
PF-00835231 inhibits SARS CoV-1 3CL pro with IC50 of 4 nM, displaying IC50 values of >10 μM against many of the other proteases and possessing modest levels of inhibition of cathepsin B (IC50 = 1.3 μM) and rhinovirus 3Cpro (IC50 = 1.7 μM).
PF-00835231 demonstrated potent inhibitory activity against all tested coronavirus 3CLpro including members of alpha-coronaviruses (NL63-CoV, HCoV-229E, PEDV, FIPV), beta-coronaviruses (HKU4-CoV, HKU5-CoV, HKU9-CoV, MHV-CoV, OC43-CoV, HKU1-CoV), and gamma-coronavirus (IBV-CoV), with Ki values ranging from 30 pM to 4 nM.
PF-00835231 exhibited viral effect against SARS-CoV-2 in cell culture, also showed potential synergy with remdesivir in HeLa-ACE2 cells.
PF-00835231 demonstrateed in vivo effect in mouse models of SARS-CoV and SARS-CoV-2 infection.

物理化学性质&存储条件

分子量 472.542
分子式 C24H32N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide

参考文献

1. de Vries M, et al. J Virol. 2021 Feb 23;95(10):e01819-20.

2. Liu C, et al. Antiviral Res. 2021 Mar;187:105020.

3. Hoffman RL, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.

4. Robert L Hoffman, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: