PF-00446687 hydrochloride | MC4R agonist | Probechem Biochemicals

Chemical Structure : PF-00446687 hydrochloride

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PF-00446687 hydrochloride (PF-446687, PF00446687)

货号: PC-60213Not For Human Use, Lab Use Only.

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.

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生物&药学活性

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
PF-00446687 displays >100-fold selectivity over MC1R/1 uM).
PF-00446687 is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

物理化学性质&存储条件

分子量	507.06
分子式	C28H37ClF2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol hydrochloride

参考文献

1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97.

2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

PF-00446687 hydrochloride (PF-446687, PF00446687)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-00446687 hydrochloride (PF-446687, PF00446687)

生物&药学活性

物理化学性质&存储条件

参考文献

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