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首页-小分子抑制剂&激动剂-GPCR-Melanocortin Receptor-PF-00446687
PF-00446687

Chemical Structure : PF-00446687

CAS No.: 862281-92-3

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PF-00446687 (PF-446687, PF00446687)

货号: PC-60214Not For Human Use, Lab Use Only.

PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
    PF-00446687 displays >100-fold selectivity over MC1R/1 uM).
    PF-00446687 is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

    物理化学性质&存储条件

    分子量 470.593
    分子式 C28H36F2N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[(3S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl]methanone

    参考文献

    1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97.

    2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

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