PEPA |CAS:141286-78-4 Probechem Biochemicals

Chemical Structure : PEPA

CAS No.: 141286-78-4

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PEPA

货号: PC-43078Not For Human Use, Lab Use Only.

PEPA is an allosteric potentiator of AMPA receptors, potentiates glutamate responses by 50-fold in oocytes expressing GluRCflop (EC50=50 uM).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

PEPA is an allosteric potentiator of AMPA receptors, potentiates glutamate responses by 50-fold in oocytes expressing GluRCflop (EC50=50 uM).
PEPA dose dependently potentiates glutamate-evoked currents in Xenopus oocytes expressing AMPA (GluRA-GluRD), but not kainate (GluR6 and GluR6+KA2) or NMDA (zeta1 + epsilon1-epsilon4), receptor subunits at 1-200 uM.
PEPA markedly slows the rate of onset of desensitization and potentiates steady-state equilibrium currents evoked by glutamate with subunit (GluRC >/= GluRD > GluRA) and splice-variant (flop > flip) selectivity.

物理化学性质&存储条件

分子量	402.436
分子式	C16H16F2N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-

参考文献

1. Sekiguchi M, et al. J Neurosci. 1997 Aug 1;17(15):5760-71.

2. Sekiguchi M, et al. Br J Pharmacol. 1998 Apr;123(7):1294-303.

3. Shen Y, et al. Neuroscience. 1999 Mar;89(3):979-90.

PEPA

生物&药学活性

物理化学性质&存储条件

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PEPA

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