PEAQX |CAS:459836-30-7 Probechem Biochemicals

Chemical Structure : PEAQX

CAS No.: 459836-30-7

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PEAQX (NVP-AAM077, NVP-AAM 077)

货号: PC-42957Not For Human Use, Lab Use Only.

PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM).

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg		Get quote

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生物&药学活性

PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM).
PEAQX (NVP-AAM077) shows high binding affinity for NMDA receptors (IC50=8 nM), induces social facilitation in adolescent male rats (1.25, 3.75mg/kg).
PEAQX (NVP-AAM077) enhances locomotor activity in response to PCP challenge in vivo.

物理化学性质&存储条件

分子量	454.2117
分子式	C17H17BrN3O5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phosphonic acid, P-[[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]-

参考文献

1. Auberson YP, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.

2. Anastasio NC, et al. Neuroscience. 2009 Nov 10;163(4):1181-91.

3. Bortolato M, et al. J Neurosci. 2012 Jun 20;32(25):8574-82.

4. Morales M, et al. Psychopharmacology (Berl). 2014 Apr;231(8):1797-807.

PEAQX (NVP-AAM077, NVP-AAM 077)

生物&药学活性

物理化学性质&存储条件

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PEAQX (NVP-AAM077, NVP-AAM 077)

生物&药学活性

物理化学性质&存储条件

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