PDSinh-C01

Chemical Structure : PDSinh-C01

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货号: PC-27732Not For Human Use, Lab Use Only.

PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters.
PDSinh-C01 (25 uM) does not significantly inhibit the transport activities of Slc4a1 (anion exchanger 1 [AE1]), Slc26a3 (chloride anion exchanger [CLD]/downregulated-in-adenoma [DRA]), Na-K-Cl cotransporter (NKCC1;Slc12a2), or ENaC.
PDSinh-C01 potentiates the acute diuretic efficacy of furosemide.
PDSinh-C01 reduces the diuretic efficacy of hydrochlorothiazide.

物理化学性质&存储条件

分子量	401.54
分子式	C20H23N3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3,4-dimethyl-1H-pyrazol-5-yl)-2-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)thiophene-3-sulfonamide

参考文献

1. Lipani A, et al. Eur J Med Chem. 2026 Jan 15;302(Pt 2):118325.

2. Onur Cil, et al. J Am Soc Nephrol. 2016 Dec;27(12):3706-3714.

PDSinh-C01

生物&药学活性

物理化学性质&存储条件

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PDSinh-C01

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物理化学性质&存储条件

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