PDM-631 | PDE2A inhibitor | Probechem Biochemicals

Chemical Structure : PDM-631

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PDM-631 (PDM 631, PDM631)

货号: PC-60365Not For Human Use, Lab Use Only.

PDM-631 is a potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively.

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生物&药学活性

PDM-631 is a potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively.
PDM-631 displays >2,000-fold selectivity against other PDEs.
PDM-631 increases object recognition memory, does not show an antipsychotic-like effect in mice.
PDM-631 is a good pharmacological tool that can be used to investigate the role of PDE2A and may have therapeutic potential for the treatment of cognitive impairments associated with schizophrenia and neurodegenerative disorders, without any extrapyramidal side effects.

物理化学性质&存储条件

分子量	392.38
分子式	C19H19F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-cyclopropyl-6-methyl-1-(1-(4-(trifluoromethoxy)phenyl)propan-2-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

参考文献

1. Maehara S, et al. Eur J Pharmacol. 2017 Sep 15;811:110-116.

PDM-631 (PDM 631, PDM631)

生物&药学活性

物理化学性质&存储条件

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PDM-631 (PDM 631, PDM631)

生物&药学活性

物理化学性质&存储条件

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