PDK1 inhibitor 7 | PDK1 inhibitor | Probechem Biochemicals

Chemical Structure : PDK1 inhibitor 7

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PDK1 inhibitor 7 (PDK1 inhibitor MP7)

货号: PC-61111Not For Human Use, Lab Use Only.

PDK1 inhibitor 7 (MP7) is a potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases.

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生物&药学活性

PDK1 inhibitor 7 (MP7) is a potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases.
MP7 specifically inhibits cellular PDK1 T-loop phosphorylation (Ser-241), inhibits p-RSK S221 in PC-3 cells with EC50 of 300 nM.
MP7 inhibits colony formation in a subset of cancer cell lines (4 of 10) and primary xenograft tumor lines (9 of 57).

物理化学性质&存储条件

分子量	516.505
分子式	C28H22F2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(3,4-difluorobenzyl)-2-oxo-N-(2-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)-1-phenylethyl)-1,2-dihydropyridine-3-carboxamide

参考文献

1. Nagashima K, et al. J Biol Chem. 2011 Feb 25;286(8):6433-48.

PDK1 inhibitor 7 (PDK1 inhibitor MP7)

生物&药学活性

物理化学性质&存储条件

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PDK1 inhibitor 7 (PDK1 inhibitor MP7)

生物&药学活性

物理化学性质&存储条件

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