PDK1 agonist PS48 | PDK1 agonist | Probechem Biochemicals

Chemical Structure : PDK1 agonist PS48

CAS No.: 1180676-32-7

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PDK1 agonist PS48 (PS48)

货号: PC-73258Not For Human Use, Lab Use Only.

PDK1 agonist PS48 is a small molecule allosteric phosphoinositide-dependent protein kinase-1 (PDK-1) agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3480	In stock
250 mg		Get quote

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生物&药学活性

PDK1 agonist PS48 is a small molecule allosteric phosphoinositide-dependent protein kinase-1 (PDK-1) agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity.
PS48 restores Akt activation in β-amyloid expressing cells.
PS48 partly restores the suppression of LTP by Aβ42, inhibited Akt phosphorylation (Akt activation) and GSK3β phosphorylation (Akt activity).

物理化学性质&存储条件

分子量	286.755
分子式	C17H15ClO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid

参考文献

1. Henry Querfurth, et al. PLoS One. 2022 Jan 21;17(1):e0261696.

PDK1 agonist PS48 (PS48)

生物&药学活性

物理化学性质&存储条件

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PDK1 agonist PS48 (PS48)

生物&药学活性

物理化学性质&存储条件

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