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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-PDE6δ-IN-1
PDE6δ-IN-1

Chemical Structure : PDE6δ-IN-1

CAS No.: 2235358-40-2

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PDE6δ-IN-1

货号: PC-25959Not For Human Use, Lab Use Only.

PDE6δ-IN-1 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PDE6δ-IN-1 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells.

物理化学性质&存储条件

分子量 618.21
分子式 C29H36ClN5O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Benzenedisulfonamide, N1-[(4-chlorophenyl)methyl]-N1-cyclopentyl-N4-(4-piperidinylmethyl)-N4-(2-pyrazinylmethyl)-

参考文献

1. Patent WO2018130625 A1.

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