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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PDE5-IN-6c
PDE5-IN-6c

Chemical Structure : PDE5-IN-6c

CAS No.: 1448419-13-3

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PDE5-IN-6c (PDE5 inhibitor 6c)

货号: PC-60093Not For Human Use, Lab Use Only.

A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1; displays >500-fold selectivity over PDE6; exhibits good efficacy in mouse model of Alzheimer's disease.

物理化学性质&存储条件

分子量 420.897
分子式 C23H21ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

参考文献

1. Fiorito J, et al. J Med Chem. 2017 Nov 9;60(21):8858-8875.

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