PDE4 inhibitor Compound A | CAS 2222609-15-4 | Probechem Biochemicals

Chemical Structure : PDE4 inhibitor Compound A

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PDE4 inhibitor Compound A (PDE4B2 inhibitor)

货号: PC-20471Not For Human Use, Lab Use Only.

PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes.

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生物&药学活性

PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes.
Compound A (1-10 mg/kg, QD, p.o.) showed dose-dependent and significant suppressive effects on glycosylated hemoglobin (GHb) and urinary albumin/creatinine ratio (UACR) in UNx-db/db mice.
Compound A suppressed pro-fibrotic and pro-inflammatory marker mRNAs and increased anti-reactive oxygen species marker mRNAs in the kidneys of UNx-db/db mice.

物理化学性质&存储条件

分子量	436.51
分子式	C24H28N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((E)-amino(dimethylamino)methylene)-4-((3aS,9bR)-8-ethoxy-7-methoxy-1,3,3a,9b-tetrahydrofuro[3,4-c]isoquinolin-5-yl)benzamide

参考文献

1. Mitsugi Ookawara, et al. Eur J Pharmacol. 2021 Mar 5;894:173852.

PDE4 inhibitor Compound A (PDE4B2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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PDE4 inhibitor Compound A (PDE4B2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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