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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PDE2 inhibitor 4
PDE2 inhibitor 4

Chemical Structure : PDE2 inhibitor 4

CAS No.: 2055160-19-3

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PDE2 inhibitor 4

货号: PC-35839Not For Human Use, Lab Use Only.

PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms.
    PDE2 inhibitor 4 exhibits excellent pharmacokinetic properties in multiple species and improves cognitive performance in both the rat Novel Object Recognition and rhesus Object Recognition assays.

    物理化学性质&存储条件

    分子量 352.317
    分子式 C16H15F3N4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-3-(hydroxymethyl)-6-methyl-1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

    参考文献

    1. Stachel SJ, et al. ACS Med Chem Lett. 2018 Jul 26;9(8):815-820.

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