PDE12 inhibitor Compound 1

Chemical Structure : PDE12 inhibitor Compound 1

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货号: PC-20981Not For Human Use, Lab Use Only.

PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.
PDE12 inhibitor Compound 1 produced increase in 2',5'-oligoadenylate (2-5A) levels in HeLa cells with pEC50 of 7.7.
PDE12 inhibitor Compound 1 inhibited the EMCV-induced cytopathic effect in HeLa Ohio cells with a pIC50 of 6.7.
PDE12 inhibitor Compound 1 inhibited HeLa Ohio cell proliferation in the absence of EMCV infection with a pIC50 of 5.7.
PDE12 inhibitor Compound 1 inhibited HRV infection with a pIC50 of 6.9.

物理化学性质&存储条件

分子量	616.49
分子式	C31H27BrFN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N#CC1=CC2=C(C=C1)C(C3=NC4=CC(Br)=C(C(N5[C@@H](CO)[C@H](C6=CC=C(F)C=C6)OCC5)=O)C=C4N3C)=CN2CC

参考文献

1. Wood ER, et al. J Biol Chem. 2015 Aug 7;290(32):19681-96.