PDDC | nSMase2 inhibitor | Probechem Biochemicals

Chemical Structure : PDDC

CAS No.: 2232878-43-0

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PDDC (nSMase2 inhibitor PDDC)

货号: PC-72748Not For Human Use, Lab Use Only.

PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
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生物&药学活性

PDDC is the first potent, selective, orally-available, and brain-penetrable nSMase2 (neutral sphingomyelinase 2) inhibitor with pIC50 of 6.57.
PDDC inhibited release of ADEVs in tissue culture and in vivo, capable of dose-dependently reducing EVs release in vitro and in vivo.
PDDC reduced these IL-1β-induced changes implicating nSMase2 inhibition as a therapeutic target for acute brain injury.

物理化学性质&存储条件

分子量	487.56
分子式	C27H29N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)pyrrolidin-3-yl)carbamate

参考文献

1. Rojas C, et al. Br J Pharmacol. 2019 Oct;176(19):3857-3870.

2. Šála M, et al. J Med Chem. 2020 Jun 11;63(11):6028-6056.

3. Tallon C, et al. Biochem Pharmacol. 2021 Dec;194:114796.

PDDC (nSMase2 inhibitor PDDC)

生物&药学活性

物理化学性质&存储条件

参考文献

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PDDC (nSMase2 inhibitor PDDC)

生物&药学活性

物理化学性质&存储条件

参考文献

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