PDD 00017273 | PARG inhibitor | Probechem Biochemicals

Chemical Structure : PDD 00017273

CAS No.: 1945950-21-9

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PDD 00017273 (PDDX-001, PDD00017273)

货号: PC-62412Not For Human Use, Lab Use Only.

PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.
PDD 00017273 inhibits the proliferation of ZR-75-1 cells and MDA-MB-436 with IC50 of 0.2 and 0.8 uM.
PDD 00017273 inhibits DNA repair with differential pharmacology to olaparib; shows no activity against CYP450 isoforms.
PDD 00017273 possesses good aqueous solubility and suitable for in vivo studies.

物理化学性质&存储条件

分子量	514.619
分子式	C23H26N6O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

参考文献

1. James DI, et al. ACS Chem Biol. 2016 Nov 18;11(11):3179-3190.

2. Gravells P, et al. DNA Repair (Amst). 2017 Apr;52:81-91.

PDD 00017273 (PDDX-001, PDD00017273)

生物&药学活性

物理化学性质&存储条件

参考文献

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PDD 00017273 (PDDX-001, PDD00017273)

生物&药学活性

物理化学性质&存储条件

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