PD180970 | p210 bcr/abl inhibitor | Probechem Biochemicals

Chemical Structure : PD180970

CAS No.: 287204-45-9

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PD180970 (PD 180970)

货号: PC-73114Not For Human Use, Lab Use Only.

PD180970 (PD 180970) is an ATP-competitive inhibitor of p210bcr/abl tyrosine kinase, inhibits autophosphorylation of p210Bcr-Abl with IC50 of 5 nM.

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
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100 mg		Get quote

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生物&药学活性

PD180970 (PD 180970) is an ATP-competitive inhibitor of p210 bcr/abl tyrosine kinase, inhibits autophosphorylation of p210Bcr-Abl with IC50 of 5 nM.
PD180970 selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells.
PD180970 inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50, 80, 80 and 170 nM respectively).
PD180970 potently inhibits p210bcr/abl autophosphorylation in vitro (IC50=5 nM).
PD180970 also potently inhibits c-Src and KIT (IC50 , 0.8 and 50 nM, respectively).
PD180970 induces autophagy and reduces neuroinflammation in animal models of Parkinson's disease.

物理化学性质&存储条件

分子量	429.27
分子式	C21H15Cl2FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. J F Dorsey, et al. Cancer Res. 2000 Jun 15;60(12):3127-31.

2. Paul La Rosée, et al. Cancer Res. 2002 Dec 15;62(24):7149-53.

3. Suresh Sn, et al. EBioMedicine. 2019 Dec;50:260-273.

PD180970 (PD 180970)

生物&药学活性

物理化学性质&存储条件

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PD180970 (PD 180970)

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