PD173955 |CAS:260415-63-2 Probechem Biochemicals

Chemical Structure : PD173955

CAS No.: 260415-63-2

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PD173955 (PD-173955)

货号: PC-42561Not For Human Use, Lab Use Only.

PD173955 is a potent, selective, ATP-competitive Src family kinases inhibitor with IC50 of 22 nM for Src.

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10 mg	￥1880	In stock
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生物&药学活性

PD173955 is a potent, selective, ATP-competitive Src family kinases inhibitor with IC50 of 22 nM for Src.
PD173955 equally inhibits Yes kinase in vitro, weakly inhibits α-FGFR and PDGFR (IC50s=1.6 uM) and no activity against IR and PKC.
PD173955 inhibits the proliferation of MDA-MB-468 and MCF-7 breast cancer cells with IC50 of 0.5 and 1 uM, respectively。
PD173955 also inhibits Bcr-Abl with IC50 of 1-2 nM, c-kit autophosphorylation (IC50=25 nM).

物理化学性质&存储条件

分子量	443.3489
分子式	C21H16Cl2N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-8-methyl-2-[[3-(methylthio)phenyl]amino]-

参考文献

1. Moasser MM, et al. Cancer Res. 1999 Dec 15;59(24):6145-52.

2. Nagar B, et al. Cancer Res. 2002 Aug 1;62(15):4236-43.

3. Wisniewski D, et al. Cancer Res. 2002 Aug 1;62(15):4244-55.

PD173955 (PD-173955)

生物&药学活性

物理化学性质&存储条件

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PD173955 (PD-173955)

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物理化学性质&存储条件

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