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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Bcr-Abl-PD173952
PD173952

Chemical Structure : PD173952

CAS No.: 305820-75-1

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PD173952 (PD 173952 )

货号: PC-22637Not For Human Use, Lab Use Only.

PD173952 is a multi-kinases inhibitor with IC50 of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk kinase respectively, induces apoptosis of Bcr-Abl-dependent hematopoietic cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD173952 is a multi-kinases inhibitor with IC50 of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk kinase respectively, induces apoptosis of Bcr-Abl-dependent hematopoietic cells.

物理化学性质&存储条件

分子量 482.37
分子式 C24H21Cl2N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(2,6-Dichlorophenyl)-8-methyl-2-[[4-(4-morpholinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Dorsey JF, et al. Leukemia. 2002 Sep;16(9):1589-95.

2. Marshall SJ, et al. Blood. 2004 Apr 1;103(7):2601-9.

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