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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FGFR-PD173074
PD173074

Chemical Structure : PD173074

CAS No.: 219580-11-7

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PD173074 (PD 173074;PD-173074)

货号: PC-42521Not For Human Use, Lab Use Only.

PD173074 is a potent, selective, ATP-competitive FGFR1 inhibitor with IC50 of ~25 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD173074 is a potent, selective, ATP-competitive FGFR1 inhibitor with IC50 of ~25 nM.
PD173074 also inhibits autophosphorylation of VEGFR2 with IC50 of 100–200 nM.
PD173074 displays >1000-fold selectivity over Src, InsR, EGFR, PDGFR, etc.

物理化学性质&存储条件

分子量 523.6702
分子式 C28H41N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 52 mg/mL
Chemical Name/SMILES

Urea, N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

参考文献

1. Mohammadi M, et al. EMBO J. 1998 Oct 15;17(20):5896-904.

2. Skaper SD, et al. J Neurochem. 2000 Oct;75(4):1520-7.

3. Nguyen PT, et al. Br J Cancer. 2013 Oct 15;109(8):2248-58.

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