PD166285 |CAS:212391-63-4 Probechem Biochemicals

Chemical Structure : PD166285

CAS No.: 212391-63-4

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PD166285 (PD-166285;PD 166285;PD 0166285)

货号: PC-60888Not For Human Use, Lab Use Only.

PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM, also inhibits the checkpoint kinases Wee1 and Myt1.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM, also inhibits the checkpoint kinases Wee1 and Myt1.
PD166285 inhibits the formation of microcapillaries on Matrigel-coated plastic at 10 nM.
PD166285 inhibits angiogenesis in mice after oral administration (1-25 mg/kg), significantly prolongs tumor regressions in vivo.

物理化学性质&存储条件

分子量	585.35
分子式	C26H27Cl2N5O2.2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

参考文献

1. Dimitroff CJ, et al. Invest New Drugs. 1999;17(2):121-35.

2. Bansal R, et al. J Neurosci Res. 2003 Nov 15;74(4):486-93.

3. Panek RL, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1433-44.

4. Wang Y, et al. Cancer Res. 2001 Nov 15;61(22):8211-7.

PD166285 (PD-166285;PD 166285;PD 0166285)

生物&药学活性

物理化学性质&存储条件

参考文献

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PD166285 (PD-166285;PD 166285;PD 0166285)

生物&药学活性

物理化学性质&存储条件

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