PD089828 (PD-089828)

Chemical Structure : PD089828

CAS No.: 179343-17-0

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货号: PC-38509Not For Human Use, Lab Use Only.

PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 uM, 1.76 uM, and 5.47 uM, respectively.
PD089828 inhibits PDGF receptor autophosphorylation in VSMC, also inhibits the PDGF-induced tyrosine phosphorylation of the 44- and 42-kDa mitogen-activated protein kinase isoforms.
PD089828 inhibits PDGF-directed migration, serum-stimulated growth of VSMC, and PDGF receptor autophosphorylation with IC50 of 0.8, 4.5 and 1.8 uM, respectively.

物理化学性质&存储条件

分子量	405.28
分子式	C18H18Cl2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)urea

参考文献

1. J M Hamby, et al. J Med Chem. 1997 Jul 18;40(15):2296-303.

2. Dahring TK, et al. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56.