PD-L1 inhibitor 4 | PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : PD-L1 inhibitor 4

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PD-L1 inhibitor 4 (PD-L1-IN-4)

货号: PC-73047Not For Human Use, Lab Use Only.

PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.

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100 mg		Get quote

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生物&药学活性

PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.
PD-L1 inhibitor 4 exhibited substantially increased binding affinity to hPD-L1, as well as PD-1/PD-L1 inhibitory activity in physiological conditions.
PD-L1 inhibitor 4 also showed a dose-dependent increase in IFN-γ secretion levels in a mixed lymphocyte reaction assay.

物理化学性质&存储条件

分子量	892.966
分子式	C50H48N6O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,2'R)-2,2'-((((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(methylene))bis(oxy))bis(2-((5-cyanopyridin-3-yl)methoxy)-4,1-phenylene))bis(methylene))bis(azanediyl))bis(3-hydroxypropanoic acid)

参考文献

1. Kawashita S, et al. Bioorg Med Chem Lett. 2019 Sep 1;29(17):2464-2467.

PD-L1 inhibitor 4 (PD-L1-IN-4)

生物&药学活性

物理化学性质&存储条件

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PD-L1 inhibitor 4 (PD-L1-IN-4)

生物&药学活性

物理化学性质&存储条件

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