PD-307243 |CAS:313533-41-4 Probechem Biochemicals

Chemical Structure : PD-307243

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PD-307243 (PD 307243;PD307243)

货号: PC-60834Not For Human Use, Lab Use Only.

A potent hERG channel activator that concentration-dependently increases the hERG current (2.1 and 3.4-fold at 3 and 10 uM, respectively) and markedly slows hERG channel deactivation and inactivation.

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生物&药学活性

PD-307243 (PD307243) is a potent hERG channel activator that concentration-dependently increases the hERG current (2.1 and 3.4-fold at 3 and 10 uM, respectively) and markedly slows hERG channel deactivation and inactivation.
PD-307243 induces instantaneous hERG current with little decay at membrane potentials from -120 to -40 mV at 3 and 10 uM, induces an I(to)-like upstroke of hERG current at more positive voltages.
PD-307243 slows the channel deactivation but has no effect on channel activation.

物理化学性质&存储条件

分子量	400.259
分子式	C20H15Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid

参考文献

1. Gordon E, et al. Mol Pharmacol. 2008 Mar;73(3):639-51.

2. Xu X, et al. Mol Pharmacol. 2008 Jun;73(6):1709-21.

3. Donovan BT, et al. Eur J Pharmacol. 2018 Jan 5;818:306-327.

PD-307243 (PD 307243;PD307243)

生物&药学活性

物理化学性质&存储条件

参考文献

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PD-307243 (PD 307243;PD307243)

生物&药学活性

物理化学性质&存储条件

参考文献

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