PD-1 inhibitor SCL-1

Chemical Structure : PD-1 inhibitor SCL-1

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货号: PC-49402Not For Human Use, Lab Use Only.

PD-1 inhibitor SCL-1 is a potent small molecule inhibitor of PD-1/PD-L1 binding and exerts potent antitumor effects.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

PD-1 inhibitor SCL-1 is a potent small molecule inhibitor of PD-1/PD-L1 binding and exerts potent antitumor effects.
PD1 inhibitor SCL-1 binds near the PD-1/PD-L1 interface and form hydrogen bonds with Ser62, Asn66, and Lys78 of PD-1.
PD1 inhibitor SCL-1 exhibited moderate inhibitory activities against PD-1/PD-L1 binding compared to an anti-PD-1 antibody, SCL-1 exerted markedly weaker cytotoxic effects on target cells.
PD1 inhibitor SCL-1 (50 mg/kg) exerted significant antitumor effects on PD-L1+ SCC-3 tumors, which were dependent on CD8+ T cell infiltration and PD-L1 expression in tumors.

物理化学性质&存储条件

分子量	396.418
分子式	C18H23F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-methylpiperidin-1-yl)-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl] piperidin-4-yl]methanone

参考文献

1. Akiyama Y, et al. Anticancer Res. 2022 Nov;42(11):5233-5247.