PD-166866 |CAS: 192705-79-6 Probechem Biochemicals

Chemical Structure : PD-166866

CAS No.: 192705-79-6

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PD-166866 (PD 166866;PD166866)

货号: PC-42352Not For Human Use, Lab Use Only.

PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM).

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

PD-166866 is a potent, selective, ATP competitive FGFR1 inhibitor with IC50 of 52.4 nM, has no effect on c-Src, PDGFR-β, EGFR or InsR tyrosine kinases or on MEK, PKC and CDK4 (IC50>50 uM).
PD-166866 inhibits FGFR-1 autophosphorylation in NIH 3T3 cells and L6 cells with IC50 of 10.8 and 3.1 nM, respectively.
PD-166866 inhibits bFGF-stimulated cell growth of L6 cells with IC50 of 24.1 nM, also is a a potent inhibitor of microvessel outgrowth (angiogenesis) from cultured artery fragments of human placenta.

物理化学性质&存储条件

分子量	396.44296
分子式	C20H24N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10.33 mg/mL
Chemical Name/SMILES	Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

参考文献

1. Panek RL, et al. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.

2. Sun JZ, et al. Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L155-63.

3. Cassina P, et al. J Neurochem. 2005 Apr;93(1):38-46.

4. Calandrella N, et al. J Exp Clin Cancer Res. 2007 Sep;26(3):405-9.

PD-166866 (PD 166866;PD166866)

生物&药学活性

物理化学性质&存储条件

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PD-166866 (PD 166866;PD166866)

生物&药学活性

物理化学性质&存储条件

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