PCCR-1 | RORγ inhibitor | Probechem Biochemicals

Chemical Structure : PCCR-1

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PCCR-1 (RORγ inhibitor PCCR-1)

货号: PC-38747Not For Human Use, Lab Use Only.

PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.

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生物&药学活性

PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.
PCCR-1 demonstrates promising potency for IL-17A inhibition in human and canine PBMCs and mouse splenocytes with no significant impact on Th1 and Th2 cytokines.
PCCR-1 exhibits significant efficacy in the acute CS model with dose-dependent inhibition of the PD biomarkers, effectively inhibited IL-17A release in whole blood and BALf samples from COPD patients.

物理化学性质&存储条件

分子量	541.614
分子式	C28H29F2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2,4-difluorophenoxy)propan-2-yl)-1-ethyl-1H-benzo[d]imidazol-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

参考文献

1. Desai H, et al. Sci Rep. 2022 May 24;12(1):8744.

PCCR-1 (RORγ inhibitor PCCR-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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PCCR-1 (RORγ inhibitor PCCR-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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