PCC0105003 | MARK inhibitor | Probechem Biochemicals

Chemical Structure : PCC0105003

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PCC0105003 (PCC 0105003)

货号: PC-21576Not For Human Use, Lab Use Only.

PCC0105003 is a small molecule microtubule affinity-regulating kinases (MARKs) inhibitor with IC50 of 3.0, 2.0, 2.67 and 2.67 nM for MARK1, 2, 3 and 4 repectively.

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生物&药学活性

PCC0105003 is a small molecule microtubule affinity-regulating kinases (MARKs) inhibitor with IC50 of 3.0, 2.0, 2.67 and 2.67 nM for MARK1, 2, 3 and 4 repectively.
PCC0105003 treatment partially attenuated pain-like behaviors along with improved cognitive deficit, anxiogenic-like behaviors and motor coordination in SNL rats.
PCC0105003 reversed synaptic plasticity at the functional and structural levels by suppressing NR2B/GluR1 and EB3/Drebrin signaling pathways both in amygdala and spinal dorsal horn.

物理化学性质&存储条件

分子量	419.41
分子式	C19H20F3N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-((1H-pyrazol-3-yl)methyl)-N2-(4-morpholinophenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine

参考文献

1. Yao-Qin Shi, et al. Br J Pharmacol. 2023 Dec 19. doi: 10.1111/bph.16303.

PCC0105003 (PCC 0105003)

生物&药学活性

物理化学性质&存储条件

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PCC0105003 (PCC 0105003)

生物&药学活性

物理化学性质&存储条件

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