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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Nitric Oxide Synthase (NOS)-PCC-0105002
PCC-0105002

Chemical Structure : PCC-0105002

CAS No.:

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PCC-0105002 (PCC0105002 )

货号: PC-47005Not For Human Use, Lab Use Only.

PCC-0105002 is a novel small molecule inhibitor of PSD95-nNOS protein-protein interaction with IC50 of 1.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PCC-0105002 is a novel small molecule inhibitor of PSD95-nNOS protein-protein interaction with IC50 of 1.4 uM.
    PCC-0105002 suppressed mechanical allodynia, thermal hyperalgesia, and abnormal dorsal horn wide dynamic range neuron discharge in the rat spinal nerve ligation (SNL) model.
    PCC-0105002 altered signaling downstream of NMDAR and thus functionally and structurally attenuating synaptic plasticity through respective regulation of the NR2B/GluR1/CaMKIIα and Rac1/RhoA pathways.
    PCC-0105002 attenuated neuropathic pain without inducing motor dysfunction in animal model.
    PCC-0105002 disrupted the PSD95-nNOS interaction in vitro and in vivo.

    物理化学性质&存储条件

    分子量 450.356
    分子式 C23H25Cl2NO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7,7-dimethylbicyclo[2.2.1]heptan-2-yl 4-((3,5-dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoate

    参考文献

    1. Zhihong Sun, et al. Toxicol Appl Pharmacol. 2021 Oct 15;429:115698.

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