Chemical Structure : PCARBTP
货号: PC-62645Not For Human Use, Lab Use Only.
PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
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PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
PCARBTP does not inhibit Kv1.1 and Kv1.5, two related members of the Kv family.
PCARBTP kills 98% of ex vivo primary chronic B-lymphocytic leukemia tumor cells while sparing healthy B cells.
PCARBTP significantly reduces tumor size in orthotopic mouse models of melanoma and pancreatic ductal adenocarcinoma.
分子量 | 839.663 | |
分子式 | C43H39INO7P | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Leanza L, et al. Cancer Cell. 2017 Apr 10;31(4):516-531.e10.
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