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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-PCARBTP
PCARBTP

Chemical Structure : PCARBTP

CAS No.: 2176486-23-8

PCARBTP

货号: PC-62645Not For Human Use, Lab Use Only.

PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
PCARBTP does not inhibit Kv1.1 and Kv1.5, two related members of the Kv family.
PCARBTP kills 98% of ex vivo primary chronic B-lymphocytic leukemia tumor cells while sparing healthy B cells.
PCARBTP significantly reduces tumor size in orthotopic mouse models of melanoma and pancreatic ductal adenocarcinoma.

物理化学性质&存储条件

分子量 839.663
分子式 C43H39INO7P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3-(((4-(4-((7-oxo-7H-furo[3,2-g]chromen-4-yl)oxy)butoxy)phenoxy)carbonyl)amino)propyl)triphenylphosphonium iodide

参考文献

1. Leanza L, et al. Cancer Cell. 2017 Apr 10;31(4):516-531.e10.

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