PC945 | Antifungal | Probechem Biochemicals

Chemical Structure : PC945

CAS No.: 1931946-73-4

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PC945 (Opelconazole, PC 945)

货号: PC-62615Not For Human Use, Lab Use Only.

Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.

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生物&药学活性

Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
Opelconazole (PC945) shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml.
Opelconazole (PC945) is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo.

物理化学性质&存储条件

分子量	682.748
分子式	C38H37F3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(4-{[(3R,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}-3-methylphenyl)piperazin-1-yl]-N-(4-fluorophenyl)benzamide

参考文献

1. Colley T, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16.

2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17.

PC945 (Opelconazole, PC 945)

生物&药学活性

物理化学性质&存储条件

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PC945 (Opelconazole, PC 945)

生物&药学活性

物理化学性质&存储条件

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